Newcastle made seven changes for Saturday's FA Cup defeat by Watford and will recall a number of key players, including top scorer Salomon Rondon.
Fellow forward Joselu is out with a sprained ankle, while midfielders Mohamed Diame, Jonjo Shelvey and Ki Sung-yueng are also sidelined.
Manchester City will monitor left-back Benjamin Mendy.
He missed City's last game after complaining of a swollen knee following his comeback from injury at Burton.
Vincent Kompany is again unavailable because of a muscle problem that has ruled him out of the last six matches.